Blockade of maitotoxin-induced oncotic cell death reveals zeiosis

摘要

BackgroundMaitotoxin (MTX) initiates cell death by sequentially activating 1) Ca²⁺ influx via non-selective cation channels, 2) uptake of vital dyes via formation of large pores, and 3) release of lactate dehydrogenase, an indication of cell lysis. MTX also causes formation of membrane blebs, which dramatically dilate during the cytolysis phase. To determine the role of phospholipase C (PLC) in the cell death cascade, , a specific inhibitor of PLC, and , an inactive analog, were examined on MTX-induced responses in bovine aortic endothelial cells.