In vitro antibacterial and antibiotic modifying activity of crude extract fractions and 3′4′7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria

摘要

BackgroundNutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present study thus aimed to investigate the in vitro antibacterial activity and antibiotic modifying activities of crude seed kernel methanol extract (MFS), fractions (MFSa-e) as well as 3′,4′,7-trihydroxyflavone from Myristica fragrans against a panel of multi-drug resistant (MDR) Gram-negative bacteria.