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Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

机译：金雀异黄素影响肝癌细胞（HEPG2 / C3A）细胞系中细胞色素P450（CYP450）基因的表达

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Background: Genistein (5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is the most abundant isoflavone in soybean, which has been associated with a lower risk of development of cancer and cardiovascular diseases. Of particular interest regarding cancer preventive properties of flavo-noids is their interaction with cytochrome P450 enzymes (CYPs). However, contradictory data report the effect of genistein on expression of СYPs enzymes.

机译：背景：染料木黄酮（5,7-二羟基-3-（4-羟基苯基）-4H-1-苯并吡喃-4-酮）是大豆中含量最丰富的异黄酮，与癌症和心血管疾病的发生风险较低有关疾病。关于黄酮类化合物的癌症预防特性特别令人感兴趣的是它们与细胞色素P450酶（CYP）的相互作用。但是，矛盾的数据报道了染料木黄酮对СYPs酶表达的影响。

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期刊名称 Bentham Open Access
作者
Sandra R. Lepri; Daniele Sartori; Simone C. Semprebon; Adrivanio Baranoski; Giuliana C. Coatti; Mario S. Mantovani;
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年(卷),期 -1(12),2
年度 -1
页码 138–144
总页数 7
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1. Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line [J] . Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon, Drug metabolism letters . 2018,第2期

机译：Genistein影响肝细胞癌（HepG2 / C3A）细胞中细胞色素P450（CYP450）基因的表达
2. Commiphora myrrha (Nees) Engl. resin extracts induce phase-I cytochrome P450 2C8, 2C9, 2C19, and 3A4 isoenzyme expressions in human hepatocellular carcinoma (HepG2) cells [J] . Zeyad Alehaideb, Ghada Alatar, Atef Nehdi, Saudi Pharmaceutical Journal . 2021,第5期

机译：Commiphora Myrrha（Nees）Engl。树脂提取物在人肝细胞癌（HepG2）细胞中诱导期I细胞色素P450 2C8,2C9,2C19和3A4同工酶表达
3. Role of cytochrome P450 2J2 on cell proliferation and resistance to an anticancer agent in hepatocellular carcinoma HepG2 cells [J] . Hwang Geun Hye, Park So Mi, Han Ho Jae, Oncology letters . 2017,第5aPta1期

机译：细胞色素P450 2J2对肝细胞癌HepG2细胞中细胞增殖和抗癌剂的作用
4. Gene Expression Differences of TNBG on Human Hepatocellular Carcinoma Cell Line QGY-7701 with cDNAMicroarray [C] . Annual Conference for Young Scientists of China Association for Science and Technology; 20041120-23; Shanghai(CN) . 2004

机译：cDNA微阵列检测TNBG在人肝癌细胞QGY-7701上的基因表达差异
5. Mechanistic Study of the Effect of CDH1 Promoter Hypermethylation on Drug Resistance and Related Gene Expression in Multidrug Resistant Human Hepatocellular Carcinoma R-HepG2 Cells. [D] . Jiang, Lei. 2010

机译：CDH1启动子甲基化对多药耐药人肝细胞癌R-HepG2细胞耐药性及相关基因表达影响的机理研究。
6. Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications [O] . Leonard J. Nelson, Katie Morgan, Philipp Treskes, -1

机译：人肝HepaRG细胞保持具有高固有CYP450活性/代谢的器官型表型并且在药物和治疗应用方面明显优于标准HepG2 / C3A细胞
7. Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line [O] . Sandra R. Lepri, Daniele Sartori, Simone C. Semprebon, 2018

机译：Genistein影响肝细胞癌（HepG2 / C3A）细胞系中细胞色素P450（CYP450）基因的表达

Genistein Affects Expression of Cytochrome P450 (CYP450) Genes in Hepatocellular Carcinoma (HEPG2/C3A) Cell Line

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