Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic anti-inflammatory and anti-catabolic properties

摘要

IntroductionChondroitin sulfate (CS) is a symptomatic slow-acting drug for osteoarthritis (OA) widely used in the clinic. The aim of this work is to find proteins whose secretion from cartilage cells under proinflammatory stimuli (IL-1β) is regulated by CS, employing a novel quantitative proteomic approach.