目的：探讨进行性核上性麻痹（PSP）的临床和影像学特点。方法回顾性分析12例临床诊断的PSP患者的临床和影像学资料。结果12例患者主要症状为运动迟缓、姿势不稳、假性球麻痹和垂直性眼肌麻痹，部分患者有认知功能障碍、小便障碍等。多数患者首发症状为运动迟缓。患者头颅MRI均可见不同程度脑萎缩，以额叶及中脑为著，部分患者出现“蜂鸟征”和“喇叭花征”改变。结论 PSP患者以运动迟缓为最常见首发症状，姿势不稳、易跌倒为常见的临床表现，垂直性眼肌麻痹最具诊断意义，头颅MRI检查有助于PSP诊断。%Objective To investigate the clinical and imaging features of progressive supranuclear paralysis (PSP). Methods 12 cases of PSP patients diagnosed clinical y were retrospectively analyzed based on clinical and imaging data. Re-sults The main symptoms of 12 PSP patients were bradykinesia, postural instability, pseudobulbar palsy and vertical ophthal-moplegia performance. Partial patients showed cognitive dysfunction and urinary disorders. The initial symptom of most patients was bradykinesia. Different levels of brain atrophy were observed in the cranial MRI of 12 patients, especial y in the frontal lobe and midbrain. The change of "hummingbird sign" and "morning glory sign"was observed in some of patients. Conclusion Bradykinesia was the most common initial symptom for PSP patients. Postural instability and easy to fal were the basic clinical manifestations. Vertical ophthalmoplegia indicated the greatest value of diagnosis Brain MRI assissed the PSP diagnosis.
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