颅内未破裂动脉瘤术后癫痫发作的危险因素分析

摘要

目的 探讨颅内未破裂动脉瘤(UIA)患者术后癫痫发作的危险因素.方法 回顾性分析189例UIA患者的临床资料,并记录术后12个月随访时改良Rankin量表(mRS)评分;采用logistic回归分析UIA术后癫痫发作的危险因素.结果 189例UIA患者术后发生癫痫17例,术前发作癫痫、动脉瘤最大直径≥15mm是术后癫痫发作的危险因素(OR=2.999、3.547,均P＜0.05).结论 术前发作癫痫、动脉瘤最大直径≥15mm与UIA术后癫痫发作有关.%Objective To analyze the risk factors of epilepsy after surgery for unruptured intracranial aneurysms(UIA).Methods The clinical data of 189 patients with UIA treated by microsurgical clipping were analyzed retrospectively.The modified Rankin scale (mRS) was assessed at 12 months after the operation.Logistic regression analysis was used to analyze the risk factors of epilepsy after surgery for UIA.Results In 189 patients with UIA,epilepsy developed in 17 cases after surgery.Logistic regression analysis showed that the history of preoperative seizures (OR=2.999,95％:1.003-8.968,P＜0.049) and maximum size of aneurysm ≥ 15mm (OR=3.547,95％CI:1.115-11.286,P＜0.05) were independent risk factors of the occurrence of epilepsy.Conclusion The history of preoperative seizures and maximum size of aneurysm ≥ 15mm are associated with epilepsy in patients with UIA after surgery.