血清游离脂肪酸检测在妊娠期胆汁淤积症诊断中的意义

摘要

目的：探讨孕妇妊娠晚期血清游离脂肪酸（FFA ），总胆汁酸（TBA ），甘胆酸（GC ）检测在诊断妊娠期胆汁淤积症（ICP ）中的意义。方法：分别用酶法、酶循环法和化学发光法测定TCP组（121例）和正常孕妇组（125例）的FFA、TBA、GC ，比较2组间的差异，并用ROC曲线分析FFA、TBA、GC在ICP诊断中的意义。结果：ICP组FFA、TBA、GC水平均明显高于正常孕妇组（ P＜0．05）；ROC曲线下面积，FFA （0．9991）＞GC （0．9449）＞TBA （0．8832）；正确诊断指数， FFA （0．9917）＞GC （0．9008）＞TBA （0．7366）。结论：FFA可作为ICP早期诊断的重要指标，FFA和GC联合检测有一定的临床意义。%Objective] To investigate the significance of serum free fatty acid (FFA) and total bile acid (associates) ,gansu-cholic acid (GC) measurement in pregnant women with late pregnancy for diagnosis of cholestasis syndrome during pregnancy (ICP) .[Method] Enzymatic ,enzyme recycling method and chemical luminescence method were carried out to determine above indexes in TCP group (121 cases ) and normal pregnant women (125 cases ) .We compared the differences between two groups using ROC curve analysis .[Result] FFA and CG levels of ICP group were significantly higher than that of normal preg-nant women ( p<0 .05 ) .The area under the ROC curve:FFA (0 .9991 ) > GC (0 .9449 ) > TBA (0 .8832 ) .Correct diag-nosis index:FFA (0 .9917) > GC (0 .9008) > associates (0 .7366) .[Conclusion] FFA can be used as an important index in early diagnosis of ICP .FFA and GC joint detection has a certain clinical significance .