神经节苷酯治疗HIE的临床疗效及对NSE的影响

摘要

目的 观察神经节苷酯治疗新生儿缺血缺氧性脑病(HIE)的临床疗效及其对神经特异性烯醇化酶(NSE)的影响.方法 65例HIE患儿随机分为对照组30例和治疗组35例,对照组给予常规治疗,治疗组在对照组的基础上加用神经节苷酯.观察两组患儿的临床疗效及指标恢复正常时间,并比较两组患儿治疗前后NSE水平.结果 治疗组总有效率88.6%,对照组73.3%,差异有统计学意义(P<0.05);治疗组患儿临床指标恢复正常时间早于对照组,差异有统计学意义(P<0.05或P<0.01);治疗组治疗后NSE水平较治疗前下降比对照组更为明显(P<0.05).结论 神经节苷酯治疗HIE的临床疗效明显,并可降低NSE水平.%Objective To observe the clinical effect of Ganglioside on neonates with hypoxie-ischemic encephalopathy ( HIE ) and its impact on neuron-specific enolase ( NSE ) . Methods 65 neonates with HIE were randomly divided into the control group ( n=30 ) and treatment group (n=35 ) . The control group received conventional therapy and the treatment group added Ganglioside on the basis of the control group. The clinical effect and clinical symptoms recover}' time of the two groups were observed, and the level of NSE before and after treatment of the two groups was compared. Results The total effective rate was 88.6% in the treatment group, which was significantly higher than that in the control group ( P<0.05 ) . Compared with the control group, the recovery time of clinical symptoms in the treatment gorup were significant shorter. (P<0.05, P<0.01 ) and the NSE level after treatment declined more significantly ( P<0.05 ) . Conclusion The clinical effect of ganglioside treatment on HIE is obvious and it can reduce the levels of NSE