丁苯酞注射液对急性脑梗死患者血管内皮功能的影响

摘要

Objective To observe the effect of Butyl phthalide and sodium chloride injection on the change of endothelial function in patients with acute cerebral infarction.Methods 106 patients were randomly divided into study group 57 cases and control group 49 cases. Two groups of patients were given conventional treatments,the study group were on the basis of the treatment with butyl phthalide and sodium chloride injection 100 ml,Bid. To observe the change of NIHSS score,VEGF,ET-1and NO before ang after treatment for 2 weeks.Results There were no significantly difference in NIHSS score,VEGF、ET-1、NO in the two groups before treatment(P>0.05). The NIHSS score and expression of ET-1 were significantly lower in the studygroup than control group (P<0.05),the serum of VEGF、NO were decreased(P<0.05). Compared with the two groups,the curative effect of the study group was superior to the control group(P<0.05).Conclusion Butyl phthalide and sodium chloride injection could increased NIHSS score and endothelial function,and promote the recovery of neural function.%目的：探讨丁苯酞氯化钠注射液对急性脑梗死患者血管内皮功能的影响。方法将106例急性脑梗死患者随机分为观察组57例，对照组49例。两组患者均给予常规治疗，观察组在此治疗基础上加用丁苯酞氯化钠注射液100ml静脉滴注，2次/d。分别检测两组患者治疗前及治疗2周后根据美国国立卫生院神经功能缺损评分（NIHSS），血管内皮生长因子（VEGF）、内皮素-1（ET-1）、一氧化氮（NO）水平。结果治疗前，两组患者NIHSS评分及血清VEGF、ET-1、NO水平比较，差异无统计学意义（P>0.05）。治疗2周后与对照组比较，观察组患者NIHSS评分及ET-1水平明显降低（P<0.05），血清VEGF、NO水平明显升高（P<0.05）；总有效率比较，观察组疗效明显优于对照组（P<0.05）。结论丁苯酞氯化钠注射液能明显降低急性脑梗死患者NIHSS评分，提高血管内皮功能，促进神经功能的恢复。