糖化血红蛋白与冠状动脉病变相关性的研究

摘要

Objective To investigate the relationship between HbA1c level and severity of coronary artery disease. Methods A total of 254 patients with angina pectoris or myocardial ischemia in ECG were divided into three groups according to the level of HbA1c.one hundred and two patients were in group A with HbA1c<7.0%;ninety five patients in group B with 7.0%≤HbA1c<9.0%;fifty seven patients were in group C with HbA1c≥9.0%,theangiographic characteristics of coronary artery among them were analyzed and the Gensini score were compared between the there groups. Results The level of body mass index,waist circumference, fasting plasma glucose,total cholesterol,triglyceride,uric acid in three group were different,and the differences were significant. Along with the increased HbA1c level,theprevalence of coronary heart disease was significantly higher(P<0.05),the HbA1c level had a positive correlation with number of diseased coronary branches,Gensini score.(r=0.243,P<0.01;r=0.248,P<0.01). Conclusion HbA1c is an independent risk factor in patients with coronary artery disease,and well control of glucose is critical for the treatment of CHD.%目的：探讨糖化血红蛋白（HbA1c）与冠状动脉病变（简称冠脉病变）程度的相关性及临床意义。方法将因有心绞痛病史或心电图有心肌缺血表现而进行冠脉造影的254例患者根据其HbAlc水平分组。A组：HbA1c<7.0%（n=102）；B组：7.0%≤HbA1c<9.0%（n=95）；C组：HbA1c≥9.0%（n=57）。据冠脉造影结果，评价HbA1c水平与冠心病，冠脉病变支数及冠脉病变程度积分（Gensini积分）之间的相关性。结果3组间BMI、WC、FPG、TG、TC、UA等水平差异均有统计学意义（P<0.05）。随着HbA1c水平的升高，冠心病患病率升高（P<0.05）。HbA1c水平与冠脉病变支数及病变程度积分显著相关（r=0.243，P<0.01；r=0.248，P<0.01）。结论随HbA1c水平升高，冠脉病变逐渐复杂且严重，故有效控制血糖水平对预防冠心病及冠心病进展甚为重要。