臭氧玻璃酸钠及两者联合治疗膝关节骨关节炎临床疗效的对比研究

摘要

Objective To compare the clinical effect of knee osteoarthritis with ozone,sodium hyaluronate and combination treatment,and to explore better treatments. Methods 120 osteoarthritis knees were randomly divided into 3 groups with 40 each.Group A were treated with intra-articular injection of medical ozone combined sodium hyaluronate;group B were treated with ozone alone;group C were treated with sodium hyaluronate alone. The VAS of pain and he WOMAC osteoarthritis index scores were recorded before the treatment and 1,2 and 3 months after treatment. Results The VAS and WOMAC osteoarthritis index scores were significantly decreased at the 1,2 and 3 months after treatment(P<0.05).Compared with group B and C,the VAS score and the WOMAC osteoarthritis index score of 1,2 and 3 months after treatment is lower in group A(P<0.05). Conclusion By using VAS scores and WOMAC osteoarthritis index scores,ozone conbined with sodium hyaluronate could bring better clinical effect to knee osteoarthritis,better long-term effects,and no adverse reactions,high clinical value.%目的：观察臭氧（O3）、玻璃酸钠及两者联合治疗膝关节骨性关节炎的临床效果，探索缓解该疾病症状更好的治疗方式。方法根据美国风湿病年会2001年制定的膝骨性关节炎诊断标准纳入82例患者，共120膝关节，随机分为A、B、C三组各40膝关节。关节腔内注射医用O3联合玻璃酸钠；B组关节腔内注射医用O3；C组关节腔内注射玻璃酸钠。记录治疗前及治疗后1、2、3个月VAS评分、WOMAC骨性关节炎指数评分。结果三组患者在治疗后1、2、3个月的VAS评分及WOMAC骨性关节炎指数评分与治疗前比较差异有统计学意义（P<0.05）；A组与B、C两组在治疗后1、2、3个月VAS评分及WOMAC骨性关节炎指数评分比较差异有统计学意义（P<0.05）。结论通过使用VAS评分及WOMAC骨性关节炎指数评分，O3联合玻璃酸钠治疗膝关节骨性关节炎的临床效果更佳，远期效果更好且无不良反应，临床应用价值高。