米诺环素对全氟异丁烯吸入性急性肺损伤的防治效果

摘要

目的 观察米诺环素(MIN)对大鼠全氟异丁烯(PFIB)吸入性急性肺损伤(ALI)的防治效果,为寻找防治PFIB中毒的有效药物提供理论根据.方法 用自制大鼠全身暴露动态吸入染毒系统构建大鼠PFIB吸入性ALI模型.观察MIN治疗组与中毒对照组肺系数以及支气管肺灌洗液(BALF)中蛋白及磷脂含量变化.结果 MIN在PFIB染毒后lh腹腔注射给药可以减轻肺损伤,但对BALF中蛋白质和磷脂含量无影响.结论 MIN治疗PFIB吸入性ALI可以减轻PFIB染毒大鼠的肺损伤,减轻肺间质瘀血水肿的程度,但并未减少肺泡腔内液体渗出.%Objective To observe the therapeutic effect of minocycline (MIN) on acute lung injury (ALI) induced by perfluoroisobutylene (PFIB)-inhaled in the rat and to provide theoretical basis for treatment of ALI induced by PFIB.Methods The Wistar rats were exposed to gaseous PFIB in a whole body exposure system, the lung coefficient, protein content and phosphatide content of bronchial veolar lavage fluid (BALF) in PFIB-inhaled rats were measured.Results The ALI was significantly alleviated when PFIB was inhaled 1 hour later, but the protein content and phosphatide content in BALF were not significantly reduced.Conclusion MIN can reduce the degree of pulmonary interstitial edema, but can' t reduce alveolar liquid leakage.