血清CA125水平与非ST段抬高性心肌梗死患者发生主要心脏不良事件的关系

摘要

目的 探讨血清CA-125水平与非ST段抬高性心肌梗死患者发生主要心脏不良事件的关系.方法 选取非ST段抬高性心肌梗死患者125例,并随访6个月.根据入院时测定的血清CA-125水平分为CA-125(>35U/L)升高组及CA-125(≤35U/L)正常组,并根据6个月内是否发生主要心脏不良事件分为MACE组及非MACE组.利用多因素logistic回归分析CA-125与MACE发生的关系.结果 CA-125升高组36例,CA-125正常组89例,CA-125升高组血清肌钙蛋白(CTNI)、hs-CRP、pro-BNP水平和MACE发生率高于CA-125正常组,差异有统计学意义(P<0.05).MACE组23例,非MACE组102例,MACE组CA-125、血清肌钙蛋白(CTNI)、hs-CRP、pro-BNP水平均高于非MACE组,差异统计学意义(P<0.01).通过多因素logistic回归分析显示CA-125水平升高是非ST段抬高性心肌梗死患者发生主要心脏不良事件的危险因素(OR=1.233,95％CI:1.142～1.527,P<0.05).结论 血清CA-125水平升高的非ST段抬高性心肌梗死患者发生主要心脏不良事件的几率增加.%Objection To investigate the relationship between serum CA-125 level and major adverse cardiac events in patients with Non ST segment elevation myocardial infarction. Methods 125 patients with Non ST segment elevation myocardial infarction were enrolled in the department of cardiovascular medicine,and were followed up for 6 months. According to the level of serum CA-125 measured at admission,the patients were divided into CA-125 normal group(≤35U/L) and abnormal CA-125 group(>35U/L),and according to the occurrence of major adverse cardiac events within 6 months,the patients were divided into MACE group and non MACE group. Multivariate logistic regression analysis was performed for the relationship between CA-125 and MACE. Results There were 36 cases in CA-125 abnormal group and 89 cases in CA-125 normal group. The serum troponin(CTNI),hs-CRP,pro-BNP and MACE were higher in CA-125 abnormal group than in CA-125 normal group,the difference was statistically significant(P<0.05). MACE group of 23 cases,non MACE group of 102 cases,the level of serum troponin(CTNI),hs-CRP,pro-BNP in MACE group were higher than those in the non MACE group,the difference was statistically significant(P<0.01).Multivariate logistic regression analysis showed that elevated CA-125 levels were risk factors for major adverse cardiac events in patients with non ST segment elevation myocardial infarction(OR=1.233,95％CI:1.142=1.527,P<0.05). Conclusions The incidence of major adverse cardiac events in patients with non ST segment elevation myocardial infarction increases whose serum CA-125 levels elevates.