我国吡虫啉工业化合成路线探讨

摘要

回顾了我国吡虫啉工业化的历史,阐述了我国吡虫啉工业化的现状。对3-甲基吡啶氧化法、苄胺-丙醛环合法和3-甲基吡啶直接氯化法3种吡虫啉合成工艺路线进行了探讨和比较,并提出了其中存在的问题。认为3-甲基吡啶氧化法和苄胺-丙醛环合法有希望替代传统环戊二烯环合法合成吡虫啉。%This paper reviews the history of industrialization of imidacloprid,and introduces its present situation in China.Three synthesis routes of imidacloprid are discussesd and compared,and the problems of synthesis routes are also proposed.It is suggested that 3-methyl pyridine oxidation method and benzylamine-propionaldehyde cyclization method may be used as substitutes of cyclopentadienyl cyclization method.