萨丁尼亚地区经典型Kaposi肉瘤患者HLA阳性及HLA阴性的相关性调查

摘要

Background: The incidence of classic Kaposi’s sarcoma (CKS) in northern Sardi nia is one of the highest in the world. Methods: Sixty-two patients with CKS we re typed for class I and class II antigens. All patients had been born and were living in northern Sardinia. Results: In the Sardinian patients, we observed a p ositive CKS association with Cw7, DRB11104,DRB11302, DQA10302, and DQB10604, and a negative CKS association with A30, B58, Cw5, DRB11601, and DQB10502. Conclusions: The strong positive CKS association with DRB11104 and DQB10604 and negative association with B58 are particularly significant and further support the notion of a genetic predisposition to CKS.