method to determine if a patient is hla-b * 1502, kit to determine if a patient is hla-b * 1502, three probe kit to determine if a parent is hla-b * 1502, method to determine if a patient is hla-b / 5801, kit to determine if a patient is hla-b * 5801, three probe kit to determine if a patient is hla-b * 5801 and method to determine if A compound is a candidate that induces a drug-induced adverse reaction (adr) in a patient who has a hla allele associated with drug-induced adr

摘要

METHOD FOR ASSESSING A HUMAN PATIENT'S RISK DEVELOPING AN ADVERSE DRUG REACTION IN RESPONSE TO A DRUG. The present invention relates to a method for determining the presence of certain HLA alleles, such as HLA-B * 1502 or HLA-B * 5801, and a kit for performing such method. A method for assessing whether a patient is at risk for developing adverse drug reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a marker is also presented. genetic (e.g., HLA-B * 1502, HLA-B * 5801, or HLA-B * 4601).