cqvip:A 46-year-old man with a 3- year history of pyoderma gangrenosum was adm itted with ulceration (6× 5 cm), on the right leg. Previously he had been treat ed with tapering doses of prednisone (maximum dose 1 mg/kg per day); however, he had had a few exacerbations following each taper of prednisone dose. Immunoelec trophoresis demonstrated monoclonal IgA gammopathy of λ light chains. Abdomina l echography and abdominal computed tomographic scan revealed multiple splenic a bscesses. Treatmentwas started with oral prednisone (1 mg/kg per day) and cyclos porin (5 mg/kg per day) and 6 weeks later complete remission was achieved. Syste mic involvement in pyoderma gangrenosum is very rare, and according to our knowl edge there are only a few cases with spleen involvement.
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