IgA monoclonal gammopathy accompanying extranodal B cell lymphomas

摘要

From January 2008 to April 2013, seven patients with pathologically confirmed B cell lymphomas (three diffuse large B cell lymphomas, two mucosa-associated lymphoid tissue lymphomas, one follicular lymphoma, and one mixed cellu-larity classic Hodgkin's lymphoma) were found to have monoclonal IgA component by serum immunofixation elec-trophoresis (SIFE) in our facility (Table 1); meanwhile, 33 monoclonal IgGs and 88 IgMs were detected by SIFE among all B cell lymphomas during the same time period. All patients were male, and the median age was 57.0 (48-71) years. A preference for A light chains was observed, but the two patients with k light chain seemed to have much higher serum IgA level [1,170 (681-1,660) mg/dl vs. 380 (294-552) mg/dl]. Both serum IgG [845 (270-1,424) mg/dl] and IgM [63 (4-182) mg/dl] levels were decreased to variable extents. No overt plasmacytosis or plasma cell dyscrasia was found by bone marrow smear or biopsy.