Objective: To assess the obstetric outcome of pregnancies resulting from in vi tro maturation (IVM) and IVF-ET of immature oocytes retrieved from women with p olycystic ovary syndrome (PCOS). Design: Prospective observational study. Settin g: University fertility clinic. Patient(s): One hundred thirty-nine women under going 203 IVM treatment cycles. Intervention(s): Immature oocyte recovery from u nstimulated ovaries. In vitro oocyte maturation and fertilization. Fresh ET and assessment of obstetric outcomes in the pregnant women. Main Outcome Measure(s): Pregnancy and obstetric outcome. Result(s): Forty-one pregnancies were obtaine d in 187 ETs, resulting in a pregnancy rate of 21.9%. Except for three patients lost to follow-up in these pregnancies, the abortion and live birth rates were 36.8%(14 of 38) and 63.2%(24 of 38), respectively. The mean (±SD) gestationa l age and birth weight at delivery for singletons were 38.4 ±2.0 weeks (range, 33-41.6 weeks) and 3,252 ±.516 g (1,750-4,100 g), respectively. For twins the se were 36.7 ±1.9 weeks (34.6-39 weeks) and 2,361 ±.304 g (1,900-2,990 g), r espectively. Pregnancy complications occurred in five patients (13.2%); these i ncluded preterm labor (n = 3) and placenta previa (n = 2). Two patients (5.3%) had a major congenital anomaly diagnosed by ultrasonography. Conclusion(s): The abortion rate, gestational age and birth weight at delivery, and obstetric compl ications of pregnancies conceived by IVM-ET in women with PCOS were comparable with those of other women with PCOS being treated by conventional IVF-ET. In vi tro maturation followed by IVF-ET seems to be a useful treatment option for wom en with PCOS, thus avoiding the risk of ovarian hyperstimulation syndrome.
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