cqvip:Background: Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations. Methods: Polymerase chain reaction sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA-DQA1, and -DQB1, alleles among 187 patients with vitiligo and 273 healthy controls through Epi Info version 6 package (Centers for Disease Control and Prevention, Atlanta, GA, USA). Results: The frequencies of HLA-DQA1 0302(OR = 1.98, Pc< 0.01), -DQB1 0303 (OR = 3.14, Pc< 0.001), and -DQB1 0503 (OR = 3.36, Pc < 0.05) alleles were significantly increased in patients with vitiligo compared with controls, and HLA-DQA1 0501 (OR = 0.40, Pc < 0.01) allele frequencywas highly decreased. HLA-DQA1 0302 (OR = 5.19, Pc < 0.001), -DQA1 0601 (OR= 2.95,Pc <0.05), -DQB1 0303 (OR= 4.50, Pc < 0.001), and -DQB1 0503 (OR = 6.69, Pc < 0.001) alleles were positively associated, whereas HLA-DQA1 0501 (OR = 0.05, Pc < 0.001) allele was negatively associated with childhood vitiligo patients, and HLA-DQB1 0303 (OR = 2.76, Pc < 0.001) allele was positively associated with adult vitiligo patients compared with controls. The frequency of HLA-DQB1 0303 (OR = 3.72, Pc < 0.001) allele was significantly increased in localized vitiligo patients vs. controls, whereas HLA-DQA1 0302 (OR = 2.47, Pc < 0.01), -DQB1 0303 (OR = 2.67, Pc <0.01), and -DQB1 0503 (OR = 4.46, Pc <0.01) allele frequencies were significantly increased and -DQA1 0501 (OR = 0.27, Pc <0.01) allele frequency was highly decreased in generalized vitiligo patients. Conclusions: HLA-DQA1 0302, DQA1 0601, -DQB1 0303, and -DQB1 0503 alleles could be susceptible alleles of vitiligo, while HLA-DQA1 0501 allele could be a protective allele in Chinese Hans. There may be different genetic backgrounds between vitiligo patients of childhood and adult, localized and generalized.
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