ABSTRACT:Objective To study the method effect and principle of applying small-dose urokinase to intravenous inject and drip to prevent vascular crisis after replantation. Methods Replantation of Severed Finger and therapy after operation of 83 cases 98 fingers were analyzed retrospectively, the cases were divided into thrombolysis group and control group, in the thrombolysis group apply small-dose urokinase to intravenous inject and drip after replantation , in the control group not to use urokinase. Result To observe and contrast 45 cases 51 fingers of thrombolysis group, and 38 cases 47 fingers of control group, the vascular crisis occurrence rate are 8.1%and 18.7%respectively, the finger necrosis rate are 6.1%and 16.1%respectively, statistically significant differences P<0.05. Conclusion the preventive therapy using urokinase can dissolve microthrombus in the early time of thrombogenesis, prevented the thrombogenesis, effectually decreased the vascular crisis occurrence rate after replantation, increase the success rate of replantation of severed Finger.%目的：研究应用尿激酶小剂量静注及静点预防再植术后血管危象的方法、效果和原理。方法回顾分析83例98指断指再植手术及术后治疗，分为溶栓组和对照组，溶栓组于再植术后应用尿激酶小剂量静注、静点治疗，对照组术后不应用尿激酶。结果观察和对比应用尿激酶组45例51指，和对照组38例47指再植，血管危象发生率分别为8.1%和18.7%，患指坏死率分别为6.1%和16.1%，统计学分析P<0.05。结论应用尿激酶预防性溶栓治疗能在血栓形成早期溶解微血栓，防止了血栓形成，有效地减少了再植术后血管危象的发生率，提高了断指再植术后成活率。
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