结直肠癌患者血脂水平变化研究分析

摘要

Objective To investigate the clinical value of serum lipid changes in patients with colorectal cancer.Methods 97 colorectal cancer patients were selected in oncology of our hospital from January 2013 to June 2016. Another 95 healthy individuals were selected as the control group. triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL - c) and low density lipoprotein (LDL - c) were measured in the two groups. Lipid levels change before and after 2 cycles of chemotherapy were observed in patients with stage III or IV colorectal cancer.Results Compared with control group, the change of TG level in patients with colorectal cancer was no statistical significance (P> 0.05), while the TC, HDL - c, LDL - c were lower than control group (P < 0.05);TG level in patients with different clinical stage of colorectal cancer was no statistically significant (P> 0.05), TC, HDL - c , LDL - c levels were decreased with the clinical stage increase(P< 0.05); After 2 cycles of chemotherapy in stage III or IV colorectal cancer patients, the change of TG levelwas no statistical significance (P> 0.05), TC, HDL - c and LDL - c levels were increased significantly (P< 0.05).Conclusion The body cholesterol levels may be associated with colorectal cancer occurrence, effectively controlling the serum lipid levels may reduce the risk of colorectal cancer.%目的：研究结直肠癌患者的血脂水平变化，探讨其临床价值。方法收集2013年1月至2016年6月在本院肿瘤内科住院结直肠癌患者97例，另选取95例健康体检者为对照组，测量两组患者的甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）水平，并观察III、IV期结直肠癌患者化疗2周期前后血脂水平变化。结果与对照组比较，结直肠癌患者TG水平变化没有统计学意义（P>0.05），而TC、HDL-c、LDL-c均低于对照组（P<0.05）；结直肠癌患者TG水平在不同临床分期差异没有统计学意义（P>0.05）， TC、HDL-c、LDL-c水平随着临床分期增加而降低（P<0.05）；III、IV期结直肠癌患者化疗2周期后，TG化疗后较化疗前水平变化无统计学意义（P>0.05），TC、HDL-c、LDL-c化疗后较化疗前水平明显升高（P<0.05）。结论机体胆固醇水平降低可能与结直肠癌发生相关，有效控制体内血脂水平可能降低结直肠癌的风险。