MicroRNA对体细胞重编程的调控研究进展

摘要

Induced pluripotent stem cells (iPSCs) research overcame the ethical issues for using embryo stem cells (ESCs) in regenerative medicine and broke a new path for autologous regenerative medicine. However, the reprogramming efficiency has become one of the most important barriers to iPSCs clinical transformation. Investigation of molecular mechanism during reprogramming process is of great meaning for developing efficient and safe iPS technology. Recently, microRNAs were found playing important roles in reprogramming. In this paper, we focus on microRNAs involved in somatic cell reprogramming and their potential role in this process.%诱导多能干细胞（induced Pluripotent Stem Cells，iPSCs）的研究解决了再生医学中运用ESCs所涉及的伦理学问题，为自体再生医学开辟了一条新途径。然而重编程效率的低下成为iPSCs临床转化的重要障碍之一。解析体细胞重编程过程中的分子调控机制对开发高效安全的iPSCs技术具有重要的意义。最近的研究发现microRNA家族在体细胞重编程过程中扮演着重要的角色。本文就涉及体细胞重编程的microRNA，以及对它们在控制体细胞重编程中的潜在角色进行了综述。