Alternative mechanisms for prostate-specific antigen elevation:A prospective analysis of 222 transurethral resections of prostate patients

摘要

AIM:To investigate the relationship between prostatespecific antigen(PSA)levels and(1)bladder outlet obstruction(BOO)and(2)the severity of prostate inflammation.METHODS:Two hundred and twenty-two consecutive patients undergoing transurethral resection of the prostate(TURP)were prospectively included.Patients with proven urinary tract infection and/or known prostate cancer were excluded.PSA levels,International Prostate Symptoms Score(IPSS),prostate weight,post residual volume and pressure flow parameters were determined.A histopathological assessment of the presence and severity of inflammation was also performed.RESULTS:Patients had a mean age of 69.1±8.6 years(45-90 years),with mean preoperative PSA levels of 4.7±5.4 ng/mL(0.2-32.5 ng/mL)and IPSS of 15.7±6.9(0-32).Mean PdetQmax was 96.3±34.4 cmH2O(10-220 cmH2O).The mean resected prostate weight was 39.4±27.3 g(3-189 g).Correlations were observed between PSA(logarithmic)and resected prostate weight(r=0.54;P<0.001),PSA(logarithmic)and PdetQmax(r=0.17;P=0.032),and resected prostate weight and PdetQmax(r=0.39;P<0.001).Furthermore,low correlations were observed between PSA(logarithmic)and active(r=0.21;P<0.0001)and chronic(r=0.19;P=0.005)inflammation.CONCLUSION:In this study we showed a correlation between BOO(PdetQmax)and PSA(logarithmic).Furthermore,we demonstrated a weak correlation between PSA(logarithmic)and active as well as chronic prostatic inflammation.