宫瘤消胶囊联合血府逐瘀汤治疗子宫肌瘤的疗效分析

摘要

Objective:To discuss the curative effect of Xuefuzhuyu decoction associated with Gongliuxiao capsule on elimination u -terine fibroids.Methods:A total of 98 diagnosed patients with uterine fibroids were selected from March 2011 to January 2015 in the 254th Hospital of PLA.All patients were randomized into a control group and a combined group , 49 cases in each group.The control group received Xuefuzhuyu decoction treatment ( 100 mL each time , twice per day ); the combined group received above treatment as well as Gongliuxiao capsule (oral administration, 3 grain/time, 3 times/d),and course of both groups were 3 months. Chemiluminescence method was used to detect serum progesterone (P), follicle stimulating hormone (FSH) and estradiol (E2) levels of all patients before and after treatment and the sagittal and transverse diameter of the fibroids were tested through GE colour ultrasound.After that, the size of the fibroids,menstrual period, menstrual quantity and serum hormone levels of all patients before and after the treatment were analyzed .Results:The therapeutic response rate of the combined group and the control group were 91.84%and 73.47%, the former obviously higher than the latter , and the difference was statistically significant ( P<0.05 );both of the two groups had shorter menstrual period and less menstrual quantity after treatment , so there was no statistical signifi-cance ( P?.0.05);the sizes of fibroids in combined group were greatly reduced than those of the control group , and there were statistical significance;after treatment , P, FSH and E2 level in serum were slightly lower with no statistical significance ( P>0.05).Conclusion:Xuefuzhuyu decoction associated with Gongliuxiao capsule therapy promoted blood circulation to remove blood stasis, regulated qi and released pain and reduced the size of the fibroids , which could effectively improve the clinical effect on the treatment of uterine fibroids with symptoms like menometrorrhagia and had few influence on the hormone level .It was beneficial for the recovery of physiological function and worthy for further promotion in clinic .%目的：探讨宫瘤消胶囊联合血府逐瘀汤治疗子宫肌瘤的疗效。方法：选取2011年3月至2015年1月期间我院确诊治疗的子宫肌瘤患者98例，依据随机分配原则分为对照组和联合组，每组49例，对照组患者给予血府逐瘀汤（100 mL／次，2次／d）治疗；联合组患者在此基础上给予加服宫瘤消胶囊（口服，3粒／次，3次／d）治疗，2组疗程均为3个月，采用化学发光法检测所有患者治疗前后血清中促卵泡素（ FSH）、雌二醇（ E2）、孕酮（ P）水平，通过GE彩超采集测量肌瘤矢状径和冠状径线数据，统计分析所有患者治疗前后月经期、月经量和血清激素水平，肌瘤大小测量值变化。结果：联合组和对照组患者治疗有效率分别为91.84％、73.47％，前者明显高于后者，差异有统计学意义（P＜0.05）；2组患者治疗后月经周期、经血量水平均低于治疗前，差异无统计学意义（ P＞0.05）；联合组患者治疗后肌瘤体积较对照组明显变小，差异有统计学意义（P＜0.05）；治疗前后血清中FSH、E2、P水平轻度下降，差异无统计学意义（P＞0.05）。结论：宫瘤消胶囊联合血府逐瘀汤治疗子宫肌瘤的疗法具有活血化瘀、理气止痛、缩小瘤体之功效，可有效改善子宫肌瘤引起的月经过多、经期腹部坠胀等临床症状，而对患者激素水平无过多影响，有利于患者生理功能的恢复，值得临床作进一步推广。