半夏白术天麻汤联合安宫牛黄丸对早期高血压脑出血患者神经功能及血清S100B、 CysC水平变化的影响

摘要

Objective:To investigate the effects of Banxia Baizhu Tianma Decoction combined with Angong Niuhuang Pill on neurological function and serum S100B and Cystatin C (CysC) levels in patients with early hypertensive intracerebral hemorrhage.Methods:A total of 78 patients with early hypertensive intracerebral hemorrhage who were admitted and treated in our hospital from May 2015 to October 2016,were randomly divided into control group and study group,each group 39 cases.The control group was treated with conventional western medicine.On the basis of conventional western medicine treatment,the study group was treated with Banxia Baizhu Tianma Decoction and Angong Niuhuang Pill.Both groups were treated continuously for 14 days.The clinical efficacy,incidence of adverse events,national institute of health stroke scale (NIHSS) at admission and end of the course,Activity Daily Rating Scale(ADL),Glasgow Coma Scale (GCS),serum S100B,CysC levels,intracranial pressure and hematoma volume changes were statistically compared between the two groups after the course of treatment.Results:The total effective rate of the study group was 92.31％ (36/39),which was higher than 69.23％ (27/39) of the control group.The difference was statistically significant (P ＜ 0.05);The levels of serum S100B and CysC in 2 groups after treatment were lower than those before treatment,and the study group was lower than the control group.The difference was statistically significant (P ＜ 0.05);After treatment,the intracranial pressure and hematoma volume of the two groups were lower than those before treatment,and the study group was smaller than the control group.The difference was statistically significant (P ＜ 0.05);There was no significant difference in the adverse reaction rate between the study group (10.25％) and the control group (7.69％,3/39) (P ＞ 0.05).Conclusion:Treatment of early hypertensive intracerebral hemorrhage using Banxia Baizhu Tianma Decoction combined with Angong Niuhuang Pill can effectively reduce the levels of serum S100B and CysC,alleviate the coma,improve the neurological function and daily living ability of the patients,reduce the hematoma volume and intracranial pressure,and improve treatment effects with higher safety.%目的:探讨半夏白术天麻汤联合安宫牛黄丸对早期高血压脑出血患者神经功能及血清S100B、胱抑素C(Cystatin c, CysC)水平变化的影响.方法:选取2015年5月至2016年10月驻马店市第一人民医院收治的早期高血压脑出血患者78例,随机数字表法分为对照组与观察组,各39例.对照组采用常规西医治疗,观察组在常规西医治疗基础上采用半夏白术天麻汤+安宫牛黄丸,2组均持续治疗14 d.疗程结束后统计比较2组临床疗效、不良反应发生率、入院时及疗程结束后神经功能缺损评分(National Institute of Health stroke scale,NIHSS)、日常生活能力评分(Activity DailyLiving Scale,ADL)、格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)、血清S100B、CysC水平、颅内压及血肿体积变化情况.2组治疗总有效率比较,观察组92.31％ (36/39)高于对照组69.23％ (27/39),差异有统计学意义(P＜0.05);治疗后2组血清S100B、CysC水平较治疗前降低,且观察组低于对照组,差异有统计学意义(P＜0.05);治疗后2组颅内压及血肿体积均较治疗前减小,且观察组小于对照组,差异有统计学意义(P＜0.05);2组不良反应发生率比较,观察组10.25％ (4/39)与对照组7.69％ (3/39)间差异无统计学意义(P＞0.05).结论:半夏白术天麻汤联合安宫牛黄丸治疗早期高血压脑出血,可有效降低血清S100B、CysC水平,缓解昏迷程度,改善患者神经功能及日常生活能力,减小血肿体积及颅内压,提高治疗效果,且具有安全性.