Influence of minimally invasive hematoma evacuation combined with nerve growth factor preparation on neurological function injury in patients with hypertensive cerebral hemorrhage

摘要

Objective: To study the influence of minimally invasive hematoma evacuation combined withnerve growth factor preparation on neurological function injury in patients with hypertensivecerebral hemorrhage. Methods: A total of 112 patients with hypertensive cerebral hemorrhagewho were treated in our hospital between July 2013 and February 2016 were collected, andaccording to random number table, they were divided into the control group (n=56) whounderwent minimally invasive hematoma evacuation therapy and the observation group (n=56)who underwent minimally invasive hematoma evacuation combined with nerve growth factorpreparation therapy. Serum contents of inflammatory mediators, nerve injury indexes andneurotransmitters were compared between two groups of patients before and after treatment.Results: Before treatment, there were no significant differences in serum contents ofinflammatory mediators, nerve injury indexes and neurotransmitters between the two groups.After treatment, serum contents of inflammatory mediators such as CRP, PCT, IL-1β and IL-6in observation group were lower than those in control group; serum contents of nerve injuryindexes such as NSE, S100B, GEAP and MBP were lower than those in control group; serumcontents of neurotransmitters such as SP, NPY, Glu and Asp were lower than those in controlgroup while GABA and Gly were higher than those in control group. Conclusion: Minimallyinvasive hematoma evacuation combined with nerve growth factor preparation can effectivelyreduce neurological function injury, and has positive clinical significance.