基于数据挖掘的常克教授治疗紫癜性肾炎用药规律研究

摘要

Objective:To discuss medicine law of Professor Change Ke when treating the disease of Henoch-Schonlein Purpura Ne phritis.Methods:Cases from Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected from January 2016 to January 2017.Frequencies analysis,cluster analysis and association rules were used to find out some medicine law from clinical prescriptions of Professor Ke Change.Results:A total of 46 kinds of herbs were used with frequency which is higher than 10％.Among all them,the heat-clearing medicinal and the tonifying and replenishing medicinal were most frequently used.The a nalysis also showed that the herbs with clod and warm properties were most frequently used.Herbs with bitter taste and sweet taste were most frequently used.Researcher got 4 clusters via Frequencies analysis and 442 rules acquried based on association rules.Conclusion:According to all above analyses,Professor Chang Ke considered toxic heat,deficiency,blood stasis,dampness and wind as important pathological factors of Henoch-Schonlein Purpura Nephritis.Hence,he took the method of heat-clearing and tonifying,frequently combined with herbs resolving stasis and eliminating dampness in treatment for.Henoch-Schonlein purpura nephritis.%目的:探讨常克教授治疗紫癜性肾炎的用药规律.方法:选取2016年1月至2017年1月成都中医药大学附属医院门诊病例,采用频数分析、聚类分析及关联规则对常克教授临床处方进行分析,探讨教授临床经验.结果:共得到使用频率≥10％的药物46味,所有药物中清热药和补虚药的使用频次最高;其药性以寒性、温性使用频次最高;其药味以苦味、甘味使用频次最高.经聚类分析得到4个聚类组,经关联规则共得到442条规则.结论:热毒、虚损、瘀血、湿邪、风邪是紫癜性肾炎的重要病理因素,教授常以清热和补虚治法,兼以化瘀、祛湿来治疗紫癜性肾炎.