曼月乐联合散结镇痛胶囊对子宫腺肌病患者子宫体积、痛经及月经的影响

摘要

目的:探讨曼月乐联合散结镇痛胶囊对子宫腺肌病患者子宫体积、痛经及月经的影响.方法:选取2015年11月至2017年2月中山市火炬开发区医院收治的子宫腺肌病患者78例,随机分为观察组与对照组,每组39例.对照组患者于宫腔处放置曼月乐,观察组在对照组的基础上口服散结镇痛胶囊,2组治疗6个月.比较2组患者临床疗效;统计并比较治疗前后2组患者子宫体积、痛经及月经情况;记录2组不良反应发生情况.结果:治疗6个月后,观察组与对照组的总有效率分别为87.18%、66.67%,观察组总有效率显著高于对照组(P＜0.05);与治疗前比较,治疗1、3、6个月后2组患者子宫体积均显著缩小,视觉模拟评分法(VAS)及月经量评分(PBAC)评分及血清癌抗原125(CA125)水平VAS、PBAC评分及血清CA125水平均显著下降(P＜0.05),且治疗后各时间点观察组患者子宫体积均显著小于对照组,观察组VAS、PBAC评分及血清CA125水平均显著低于对照组( P＜0.05);观察组不良反应总发生率(15.38%)显著低于对照组的(30.77%)(P＜0.05).结论:曼月乐联合散结镇痛胶囊治疗子宫腺肌可显著缩小患者子宫体积、改善痛经及月经量,且安全性较好.%Objective:To explore the influence of mirena combined with Sanjie Zhentong capsule on the uterine volume ,dysmenor-rhea and menstruation of patients with adenomyosis.Methods:A total of 78 patients with adenomyosis in Zhongshan Torch Develop-ment Zone Hospital from November 2015 to January 2017 were selected and randomly divided into observation group and control group,with 39 cases in each group.Patients of control group were placed mirena in the uterine cavity ,and patients in observation group were treated with oral Sanjie Zhentong capsule on the basis of the treatment in control group .Both groups were treated for 6 months.The clinical efficacies of the 2 groups were compared.The uterine volume,dysmenorrhea and menstruation of the 2 groups were compared before and after treatment ,and the adverse reactions of 2 groups were recorded.Results:The total effective rate of observation group was 87.18%,which was obviously higher than 66.67%in control group (P＜0.05).Compared with before the treatment,the uterine volume levels of 2 groups were decreased obviously in the 1st,3rd,6th month after treatment.The scores of VAS,PBAC and serum CA125 were decreased significantly in the 2 groups (P＜0.05).The uterine volume of observation group was significantly less than that of the control group at each time point after the treatment .The scores of VAS,PBAC and serum CA125 of observation group were significantly lower than that in control group at each time point after the treatment (P＜0.05). The total rate of adverse reactions in the observation group (15.38%) was significantly lower than that in the control group (30.77%) (P＜0.05).Conclusion:Mirena combined with Sanjie Zhentong capsule can significantly contract the uterine volume , improve dysmenorrhea and menstrual volume in the treatment of adenomyosis ,and the safety is better.It is worthy of clinical appli-cation.