益气化湿方联合西药治疗幽门螺杆菌感染性胃炎患者对胃黏膜的影响

摘要

目的:探讨益气化湿方联合西药治疗幽门螺杆菌(Hp)感染性胃炎患者对胃黏膜的影响.方法:选取2016年1月至2017年9月收治的Hp感染性胃炎患者118例,依据随机数字表法分为观察组与对照组,每组59例.对照组以常规西药进行治疗,观察组在对照组的基础上加用益气化湿方治疗,2组均连续治疗1个月.比较2组临床疗效及Hp清除效果;统计并比较治疗前后2组中医症状积分及胃黏膜状况.结果:治疗后观察组的总有效率与Hp阴转率分别为91.53%、88.14%,显著高于对照组的77.97%、69.49%(P＜0.05);与治疗前比较,治疗后2组胃脘胀痛、纳差、神疲乏力、大便稀溏、四肢不温等中医症状积分均显著下降(P＜0.05),且观察组显著低于对照组(P＜0.05);与治疗前比较,治疗后2组胃黏膜炎性反应细胞浸润、腺体密度、黏膜厚度及腺体形态等积分均显著下降(P＜0.01),且观察组显著低于对照组(P＜0.05或P＜0.01).结论:益气化湿方联合西药治疗Hp感染性胃炎显著缓解患者临床症状,改善其胃黏膜状况,提升Hp清除效果.%Objective:To explore the effects of Yiqi Huashi Recipe combined with western medicine on gastric mucosa in patients with Helicobacter pylori (Hp) infection gastritis.Methods:A total of 118 cases of Hp infected gastritis treated by outpatient de-partment and inpatient department of our hospital were divided into observation group and control group according to the random number table method,with 59 cases in each group.Control group was treated with routine western medicine ,and observation group was treated with Yiqi Huashi Recipe on the basis of control group.Both groups were treated for 1 month continuously.The clinical curative effect and Hp clearance effect of 2 groups were counted and compared before and after treatment ; The traditional Chinese medicine (TCM) syndrome scores and gastric mucosal status in 2 groups before and after treatment were statisticed and compared. Results:After treatment,the total effective rate and Hp negative conversion rate in observation group were 91.53% and 88.14%respectively,which were significantly higher than the 77.97%,69.49%in control group (P＜0.05).Compared with before treat-ment,the scores of TCM symptoms such as stomachache ,anorexia,fatigue,loose stool,unwarm limbs in 2 groups after treatment sig-nificantly decreased (P＜0.01).The observation group was significantly lower than control group (P＜0.05 or P＜0.01).Com-pared with before treatment ,the infiltration of inflammatory cells ,density of gland,thickness of mucosa and gland morphology scores decreased significantly in 2 group after treatment significantly decreased (P＜0.01),and observation group was significantly lower than control group (P＜0.05 or P＜0.01).Conclusion:Yiqi Huashi Recipe combined with western medicine to treat Hp infec-tious gastritis significantly alleviates the clinical symptoms ,improves the gastric mucosal condition ,and promotes the Hp clearance effect,which is worthy of clinical promotion.