补阳还五汤联合依达拉奉对脑卒中患者血流变学及MMPs的影响

摘要

目的:探讨补阳还五汤联合依达拉奉治疗脑卒中的疗效及对患者血流变学、基质金属蛋白酶(MMPs)的影响.方法:选取2014年3月至2017年9月湖北省黄冈市脑血管病医院收治的脑卒中患者80例,依据随机数字表法分为观察组与对照组,每组40例.2组均给予常规治疗,对照组静脉滴注依达拉奉,观察组在对照组的基础上采用补阳还五汤治疗,2组连续治疗2周.比较2组患者临床疗效、治疗前后血流变学及MMPs等指标.结果:治疗后观察组的总有效率为95.00%,显著高于对照组的77.50%(P<0.01);与治疗前比较,治疗后2组HS、LS、PV、Hct及Fib水平均显著下降(P<0.01),且观察组显著低于对照组(P<0.05或P<0.01);与治疗前比较,治疗后2组血清MMP-2、MMP-9水平显著下降, VEGF水平显著升高,且2组间存在显著差异(P<0.01).结论:补阳还五汤联合依达拉奉治疗脑卒中可有效调节患者紊乱的血流变学,降低MMPs水平,同时改善其血管功能,进而抑制脑卒中的病情进展,临床疗效显著.%Objective:To investigate the effects of Buyang Huanwu Decoction combined with edaravone on hemorrheology and MMPs in patients with stroke.Methods:A total of 80 cases of stroke patients in our hospital were selected and randomly divided into observation group and control group according to random number table method, with 40 cases in each group.Patients in 2 groups were given conventional treatment.The control group was treated with intravenous infusion of edaravone, and observation group was treated with Buyang Huanwu Decoction based on that of the control group.All the patients were treated for 2 weeks.The clinical efficacy,hemorheology indexes and MMPs of patients in 2 groups before and after treatment were compared.Results:After treatment,the total effective rate of observation group was 95%,which was significantly higher than 77.50% in the control group (P<0.01);compared with the levels before treatment,the HS,LS,PV,Hct,and Fib of 2 groups decreased significantly after treatment(P<0.01),and observation group was significantly lower than those of control group(P<0.05 or P<0.01); com-pared with the levels before treatment,the serum MMP-2,MMP-9 levels of 2 groups after treatment decreased significantly,VEGF increased significantly,and there were significant differences between 2 groups(P<0.01).Conclusion:Buyang Huanwu Decoc-tion combined with edaravone in the treatment of stroke can effectively regulate the disorder of hemorheology, reduce the level of MMPs and improve its vascular function,thereby inhibiting the progression of stroke,and the clinical efficacy is remarkable.