Objective:To observe the effects of Danqi Soft Capsules on myocardial protection and influence on blood coagulation system of patients with coronary heart disease.Methods:A total of 108 cases of coronary heart disease patients who were admitted and treated in The Central Hospital of Dalian from August 2013 to December 2016 were randomly divided into the control group and the observation group,with 54 cases in each group.The control group received the conventional percutaneous coronary intervention (PCI)treatment,and patients in the observation group were given Danqi Soft Capsules based on the therapy of the control group. Automatic immunochemiluminometric assays was used in detection of troponin T(TnT),P-selectin(PS)and P selectin glycopro-tein ligand-1(PSGL-1)levels to evaluate myocardial protective effect.Coronary blood flow situation was detected by TIMI flow grade assessment;data analysis of clinic effects of patients in the two groups before and after treatment were performed by indexes of prothrombin time(PT),two D-dimer level,blood platelet count,nitric oxide(NO)concentration,anti X factors activity peak, and plasma endothelin concentration of-1(ET-1).Results:1)Compared with the situation before treatment,the grade of TIMI blood flow classification increased significantly(P<0.05),among which the number of cases in the observation group was larger than that in the control group(P<0.05).2)Compared with the situation before treatment,TnT,PS and PSGL-1 of the two groups of patients were significantly decreased(P<0.05),and the observation group decreased slightly when compared with the stability of the control group(P<0.05).3)The platelet count and endothelin in the observation group were significantly lower than that in the control group(P<0.05),while the peak activity of anti X factor and nitric oxide were higher than those in the control group (P<0.05).There was no statistically significant difference between the two groups in prothrombin time and D -two level(P>0.05).Conclusion:Danqi Soft Capsules can effectively improve the blood coagulation system function in patients with coronary heart disease,which can improve the coagulation system function and had the effects of good myocardial protection.%目的:观察丹七软胶囊对冠心病患者的心肌保护作用及对凝血系统功能的影响.方法:选取2013年8月至2016年12月大连市中心医院收治的冠心病患者108例,随机分为对照组与观察组,每组54例,对照组常规进行冠状动脉介入(PCI)治疗,观察组在对照组基础上予丹七软胶囊.采用全自动免疫化学发光法对PS、PSGL-1、TnT的水平进行检测评估心肌保护作用;采用TIMI血流分级评估患者冠脉血流情况,同时检测治疗前后2组凝血酶原时间、D-二聚体、血小板计数、一氧化氮浓度、抗X因子活性峰值和血浆内皮素-1(ET-1)浓度的水平,并对其临床疗效进行数据分析.结果:1)与治疗前比较TIMI血流分级Ⅲ级占比显著升高(P<0.05),其中观察组升高例数优于对照组(P<0.05).2)与治疗前比较,2组治疗后TnT、PS和PSGL-1均有一定程度的上升(P<0.05),其中观察组上升幅度更小,较对照组稳定(P<0.05).3)观察组的血小板计数、血浆内皮素水平明显低于对照组(P<0.05),而一氧化氮和抗X因子活性峰值则明显高于对照组(P<0.05).2组凝血酶原时间和D-二聚体水平比较,差异无统计学意义(P>0.05).结论:丹七软胶囊治疗冠心病,可有效改善患者的凝血系统功能,起到良好的心肌保护作用.
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