济生肾气汤加减治疗女性更年期特发性水肿的临床研究

摘要

Objective: To assess curative effects of modified JiSheng ShenQiTang in treating idiopathic edema in menopausal women. Method: 180 cases of menopausal women with idiopathic edema were randomly divided into control group (A), hydrochlorothiazide group (B) and treatment group of JiSheng ShenQiTang (C). Other two groups were treated with corresponding drugs except control group. Clinical effects, TCM symptom quantization integral and adverse effects were observed after two weeks' treatment. Result: The optimal effect was C, the others were B and A; Comparisons of symptom quantization integral among three groups before and after the treatment indicated significant differences (P<0.01). Paired comparisons of symptom quantization integrals among A, B and C suggested obvious differences (P<0.01), obtained effects ranked C, B and A. Comparisons of adverse effects incidence among three groups showed statistical meanings (P<0.01), the highest was B, the others were C and A. Conclusion: JiSheng ShenQiTang, as a good recipe against female idiopathic edema, is remarkable effective in the treatment of idiopathic edema in menopausal women with less adverse effect.%目的 评价济生肾气汤治疗更年期女性特发性水肿的疗效.方法 将180 例女性更年期特发性水肿患者随机分为对照组、氢氯噻嗪治疗组、济生肾气汤治疗组,在一般治疗的基础上除对照组外,剩余2 组分别采用口服氢氯噻嗪或济生肾气汤治疗,疗程均为2周.观察患者临床疗效、中医证候量化积分值、副作用等指标的变化.结果 治疗效果最佳的是济生肾气汤治疗组,其次依次为氢氯噻嗪治疗组和对照组;治疗后3 组证侯量化积分与治疗前相比较均具有显著性差异(P<0.01),两两比较,氢氯噻嗪治疗组与对照组之间,济生肾气汤治疗组与氢氯噻嗪治疗组及对照组之间的证侯量化积分差异均具有显著性(P<0.01),不良反应发生率3 组之间的差别具有统计学意义(P<0.01),不良反应发生频率最高的是氢氯噻嗪治疗组,其次为济生肾气汤治疗组,对照组最低.结论 济生肾气汤加减治疗妇女更年期特发性水肿治疗效果明显,副作用小.