Objective:To investigate relieving itching of ZhiYang ointment for external use. Method:Rat mod-el was established with histamine phosphate and mouse with dextran, positive control group of triamcinolone ace-tonide acetate and urea ointment as well as negative control group of distilled water were found, the effects of high (200 mg/mL), moderate(100 mg/mL) and low (50 mg/mL) dosages of ZhiYang ointment on local skin pruritus of an-imals were observed. Result:ZhiYang ointment could significantly reduce the number of mouse pruritus caused by dextran and increase itching threshold of the rat tolerance to histamine phosphate. Conclusion:ZhiYang ointment for external use could alleviate the itching obviously.%目的:研究止痒油膏外敷的止痒作用。方法:用磷酸组胺致大鼠瘙痒模型,右旋糖酐致小鼠瘙痒模型,并设醋酸曲安奈德尿素软膏阳性对照组和蒸馏水阴性对照组,观察止痒油膏低剂量(50 mg/mL)、中剂量(100 mg/mL)、高剂量(200 mg/mL),对实验动物局部皮肤瘙痒的影响。结果:止痒油膏能明显降低右旋糖酐诱导的小鼠瘙痒发作次数,增加大鼠耐受磷酸组胺的致痒阈。结论:止痒油膏外敷具有明显的止痒作用。
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