妊娠期高血压对小于胎龄儿发生的影响

摘要

目的:探讨妊娠期高血压疾病对小于胎龄儿(SGA)发生的影响.方法:选取某院单胎活产小于胎龄儿(SGA) 283例,与本院同期出生的适于胎龄儿(AGA)2 865例进行病例对照分析,采用单因素和多因素非条件Logistic回归模型比较2组孕母妊娠期高血压疾病与SGA发生的相关性.结果:妊娠期高血压疾病(不分期)(OR=5.75,95％CI:3.72～8.91)、妊娠期高血压(OR=3.09,95％CI:1.54～6.21)及重度子痫前期(OR=1 3.43,95％CI:7.19～25.09)是发生SGA的危险因素.妊娠期高血压疾病(不分期)的早产SGA发生风险4倍,足月产SGA风险可提高2倍.妊娠期高血压及子痫前期均是早产SGA (OR=9.15,95％CI:2.18～38.32;OR=15.92,95％CI:5.88～43.11)及足月SGA(OR=1.96,95％CI:0.80～4.81;0R=4.44,95％CI:2.04～9.66)的危险因素.结论:妊娠期高血压疾病可显著增加SGA发病的危险性,应加强孕期保健,减少SGA的发生.%Objective:To explore the effects of pregnancy-induced hypertension on small for gestational age (SGA).Methods:All 283 SGA of single live births in a hospital were selected,compared with 2 865 of AGA born in the same period,case control analysis was perforemd.Correlation between pregnancy-induced hypertension and SGA was compared by using single factor and unconditional logistic regression model.Results:Pregnancy-induced hypertension disease (no period)(OR=5.75,95％CI:3.72～8.91),pregnancy-induced hypertension (OR=3.09,95％CI:1.54～6.21) and severe preeclampsia (OR=13.43,95％CI:7.19～25.09) were risk factors for SGA.Pregnancy-induced hypertension disease (no period) can increase four times risks for premature SGA,two times risks for term delivery SGA.Pregnancy-induced hypertension and preeclampsia were risk factors for premature SGA (OR=9.15,95％CI:2.18～38.32;OR=15.92,95％CI:5.88～43.11) and term delivery SGA(OR=l.96,95％CI:0.80～4.81;OR=4.44,95％CI:2.04 ～9.66).Conclusion:Pregnancy-induced hypertension disease can increase risks of SGA onset,we should strengthen pregnancy care to lower the occurrence of SGA.