Construction and characterization of infectious cDNA clones of enterovirus 71（EV71）

摘要

＜正＞Dear Editor,Enterovirus 71（EV71）,a member of the genus Enterovirus of the family Picornaviridae,is a single-stranded,positive-sense RNA virus that usually causes mild handfoot-mouth disease（HFMD）in children,with symptoms such as fever,diarrhea,and herpangina（Liu et al.,2013）.However,certain strains of EV71 infection can cause severe neurological complications,such as SDLY107（Sun et al.,2014）.EV71 is classified into three distinct genotypes（A–C）;the B and C genotypes are further divided into B1–B5 and C1–C5 genotypes,respectively,based on