通过给小鼠腹腔注射四氧嘧啶建立糖尿病小鼠模型，分别灌胃给予0．2mL／（10g·d）神秘果与神秘果、明月草复合物，连续给药26d，观察其对小鼠体重、空腹血糖等的影响，试验结果：对照组与各剂量组小鼠体重均显著增加，组间小鼠体重无显著差异；与模型对照组相比较，神秘果与神秘果、明月草复合物的低、中、高剂量组均显著降低四氧嘧啶糖尿病小鼠的血糖值，神秘果低、高剂量组降血糖效果接近于降糖药二甲双胍；神秘果与神秘果、明月草复合物降血糖效果与剂量间无剂量效应关系。%Animal model of diabetes was established by injecting alloxan into mice abdominalcavity, Synsepalum dulcifieum and Synsepalum dulcih'cum-Angelica keiskei mixture were lavaged into stomachs by 0.2 mL/(10g.d) with 26 days standing.The ef- fect on body weight and blood glucose was then observed in alloxan-induced diabetic mice. The results indicated that body weight of mice of control groups and dose groups significantly increased and there were no significant differences in body weight of all groups mice after lavaging stomachs. Comparing the model group, the groups in low, medium and high doses of Synsepalum dulci- fieum and its mixtures could significanly decrease blood glucose level. Hypoglycemic effects of Synsepalum dulcificum low and high dose groups showed the better and closed to metformin, but Synsepalum dulcificum and Synsepalum dulcificum-Angeli- ca keiskei mixture had no dose-response relationship on hypoglycemic effects.
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