A kind of image distortion in Optical Coherence Tomography (OCT) resulted from average refractive index changes between structures of bio tissue is discussed for the first time.Analysis is given on following situations:1) Exact refraction index changes between microstructures;2)The gradient of average refractive index change between different tissue layers is parallel to the probe beam;3) The gradient of average refractive index change is vertical to the probe beam.The results show that the image distortion of situation 1) is usually negligible;in situation 2) there is a spread or shrink effect without relative location error; however,in situation 3) there is a significant image error inducing relative location displacement between different structures.Preliminary design to eliminate the distortion is presented,the method of which mainly based on the image classification and pixel array re arrangement.
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