普仑司特的合成研究

摘要

Featuring periodicity,chronicity and repetition,bronchial asthma is a frequently occurred disease which se-verely affects human health.Pranlukast is a new oral admission drug for bronchial asthma patients. Developed by ONO company,Pranlukast was synthesized utilizing ethyl 4-hydroxybenzoate as starting material.The synthesis route was con-sisted of 4-step reactions including coupling,hydrolysis,acylchloriration and amidation.The total yield was 65.9%and HPLC purity was 99.0%,.%支气管哮喘是一种严重危害人类健康的常见多发性疾病，具有周期性、长期性、反复性的特点。普仑司特是一种新型的口服支气管哮喘治疗药物，由小野公司(日本)首先研制成功。对羟基苯甲酸乙酯经偶联、水解，酰氯化、酰胺化四步反应得到普仑司特，总收率为65.9%,，HPLC 纯度为99.0%,。