Pharmaceutical composition of pranlukast solid dispersion with improved initial dissolution rate and method for producing the same

摘要

The present invention relates to a pharmaceutical composition of pranlukast solid-dispersion with an improved initial dissolution rate and the preparation method thereof. More particularly, it relates to a pharmaceutical composition of pranlukast solid-dispersion prepared by mixing pranlukast solid-dispersion and anticoagulation agent with a certain range of HLB at a elevated temperature, which can be further granulated and capsulated, thus enabling to improve initial dissolution rate of pranlukast by solving the serious problem of pranlukast solid-dispersion to stick to capsule walls and, to improve bioavailability because it shows superior Cmax and AUC based on the same administration dose, as comared to the commercial pharmaceutical composition of pranlukast formulated by conventional method, along with the preparation method thereof.