1，6 -二磷酸果糖对外伤性脑组织继发性损害保护作用的实验研究

摘要

Objective:To discuss the protective effect of 1,6-fructose diphosphate(FDP)on secondary damage in brain injury andits mechanism. Methods: Six hours after brain injury, the contents of lipoperoxide( MDA)and superoxide dismutase( SOD)inblood and brain tissue as well as glucose and C-peptide in blood of Wistar species rates were examined. The brain tissue sam-p les were checked under hght and electric microscope. Results: FDP made the MDA contents of brain tissues and plasma andthe c-peptide level in serum dropped, inhibited blood glucose elevation, kept the SOD activity of brain in a high level and increased the SOD activity of erythrocyte so as to lighten the edema of neuron and gliocyte and the damage of mitochondrion.Conclusion: FDP is of a certain protective effect on secondary damage in brain injury. This effect is related to reducing the lipoperoxidized reaction,inhibiting blood glucose elevation, improving oxygen utilization of mitochondrion and stabilizing bi-omembrane.%目的：探讨1，6-二磷酸果糖(FDP)对外伤性脑组织继发性损害的保护作用及其机制。方法：用Wistar大鼠制作脑外伤模型，于脑损伤后6小时测定血液和脑组织中丙二醛和SOD含量及血糖和C肽含量，对脑组织标本进行光镜和电镜检查。结果：FDP使脑组织和血浆中丙二醛含量下降，并能维持脑组织SOD活性。增加红细胞SOD活力，抑制血糖升高，降低血C肽水平，使神经元和胶质细胞水肿及线粒体损害减轻。结论：FDP对脑外伤后脑组织的继发性损害具有一定的保护作用，此作用与其降低脑外伤后的脂质过氧化反应、抑制血糖升高、改善线粒体对氧的利用以及稳定生物膜的作用等有关。