Objective To explore the optimum concentration of bioactive glass that promotes early enamel caries remineralization. Methods Fresh bovine incisors were selected and used for enamel specimen preparation. All specimens were randomly divided into two groups:micro hardness group and fluorescence group. Both groups were further divided into 3%, 6%and 9%groups. These specimens were placed in containers with demineralization liquid at 37℃for 72 hours. Then they were treat with 3%, 6%and 9%bioactive glass solution respectively twice a day for 5 minutes each. Samples in all three groups were dipped circularly into an artificial demineralization solution and an artificial saliva solution for 15 days. The mi⁃crohardness of enamel surface was measured before and after demineralization and remineralization. The different value of microhardness before and after remineralization was calculated. The thickness of fluorescence beneath the surface of early enamel caries was observed to evaluate the extend of remineralization effect. Results The difference in value of micro hard⁃ness in 6%group was the highest while that in 3%group was the lowest. The differences were significant. The difference in value of demineralization depth in 6%group was greater than those in 3%and 9%groups (P<0.05). There was no statistical⁃ly significance between those in 3%group and 9%group. Conclution The optimum concentration of bioactive glass solu⁃tion that promotes the remineralization of early enamel caries is 6%, which is ideal for remineralization of early enamel caries.%目的：探讨生物活性玻璃促进早期釉质龋再矿化的最适浓度。方法收集新鲜拔除的牛切牙，制备釉质标本，随机分成显微硬度组和荧光组两大组，每组又分为3%、6%和9%小组，每小组5个标本。所有标本放在37℃人工脱矿液中脱矿72 h后，分别浸泡在质量分数为3%、6%和9%生物活性玻璃溶液内，5 min/次，2次/d，循环15 d。显微硬度仪测量脱矿前后及再矿化后牙釉质表面的显微硬度，并计算再矿化前后的显微硬度差值。荧光显微镜观察早期釉质龋表层下的荧光带厚度，从而评价再矿化效果。结果6%组的显微硬度差值最高，3%组的差值最低，差异均有统计学意义（均P<0.05）。6%组脱矿深度差值大于3%和9%组（均P<0.05），3%和9%组的脱矿深度差值差异无统计学意义。结论质量分数为6%的生物活性玻璃溶液是促进早期釉质龋再矿化的最适浓度，对早期釉质龋再矿化效果最理想。
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