CXCL16、CD36与颈动脉易损斑块并发脑梗死的关系

摘要

Objective To investigate the relationship between serum chemokine CXCL16 and CD36 in vulnerable carotid atherosclerosis plaques with large artery atherosclerosis (LAA)-stoke. Methods Fifty patients with LAA-cerebral infarction and carotid vulnerable plaque (infarction group), 50 patients with carotid vulnerable plaque (plaque group) and 50 healthy subjects in the same period (control group) were included in this study. The cervical vascular color ultrasonic inspection was performed in three groups. Data of body mass index (BMI) were calculated in three groups. Levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and fasting blood glucose (FBG) were also detected in three groups. The enzyme linked immunosorbent assay (ELISA) was used to detect the serum levels of CXCL16 and CD36 in three groups. Logistic regression analysis was used to analyse the influence factors of LAA-cerebral infarction. Results Levels of BMI, TG, TC, LDL-C and FBG were higher, and the level of HDL-C was lower in infarction group and plaque group than those in control group. Levels of TG, TC, LDL-C and FBG were significantly higher in infarction group than those of plaque group, and levels of BMI and HDL-C were significantly lower in infarction group than those in plaque group (P<0.05). Both serum levels of CXCL16 and CD36 showed significantly increased trend in control group, plaque group and infarction group. Multivariate Logistic regression analysis showed that the higher levels of TG, LDL-C, FBG, CXCL16 and CD36 were the independent risk factors for large artery atherosclerotic cerebral infarction. Conclusion Serum chemokine CXCL16 and CD36 can be used as a clinical marker of vulnerable carotid plaques. Joint detection of CXCL16 and CD36 can predict the occurrence of LAA-cerebral infarction.%目的：探讨血清巨噬细胞趋化因子配体16（CXCL16）及CD36水平与颈动脉粥样硬化易损斑块并发大动脉粥样硬化（LAA）性脑梗死的关系。方法选取颈动脉粥样硬化易损斑块合并LAA性脑梗死的患者（脑梗组）50例、有颈动脉粥样硬化易损斑块者（斑块组）50例；同期健康体检者（对照组）50例。各组均接受颈动脉彩超检查。计算各组体质指数（BMI），同时检测各组三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、空腹血糖（FBG），应用酶联免疫吸附试验（ELISA）测定各组血清CXCL16及CD36水平。Logistic回归分析颈动脉粥样硬化易损斑块发生LAA性脑梗死的影响因素。结果斑块组和脑梗组BMI、TG、TC、LDL-C、FBG水平高于对照组，HDL-C水平低于对照组；脑梗组TG、TC、LDL-C、FBG水平高于斑块组，BMI、HDL-C水平低于斑块组（P＜0.05）。对照组、斑块组及脑梗组的CXCL16和CD36水平均呈依次升高趋势（P＜0.05）。多因素Logistic回归分析显示，高TG、LDL-C、FBG、CXCL16及CD36是颈动脉粥样硬化易损斑块合并LAA性脑梗死的危险因素。结论血清CXCL16、CD36水平可作为颈动脉易损斑块的生物标志物；联合检测血清CXCL16、CD36水平有助于预测LAA性脑梗死。