亚临床甲状腺功能减退症与心血管疾病相关性的研究进展

摘要

Subclinical hypothyroidism is a metabolic disease, defined by increased thyroid-stimulating hormone (TSH) and accompanied by normal thyroid hormone levels. Recent years, many domestic and foreign studies have showed that sub⁃clinical hypothyroidism may be related with atherosclerosis and left ventricular diastolic dysfunction, which increasing the risk and mortality of cardiovascular diseases. Subclinical hypothyroidism may be associated with lipid metabolic disorders, hypertension, coagulation dysfunction, endothelial dysfunction, abnormal glucose metabolism, homocysteine, C-reactive pro⁃tein and lipoprotein. At present, controversy persists on the subclinical hypothyroidism. The aim of this study is to review the correlation between cardiovascular diseases and subclinical hypothyroidism.%亚临床甲状腺功能减退症（亚临床甲减）是一种仅有促甲状腺素水平升高而甲状腺素水平正常的代谢性疾病。国内外已有大量研究表明，亚临床甲减可能与动脉粥样硬化以及左室舒张功能障碍相关，从而导致心血管疾病的发生率和死亡率增加。亚临床甲减会影响脂质代谢异常、高血压、凝血功能异常、血管内皮功能损伤及糖代谢异常等，并与同型半胱氨酸、C反应蛋白及脂蛋白等存在相关性，从而加速动脉粥样硬化的形成。近年来亚临床甲减与心血管疾病之间的关系越来越受到关注，本文就有关两者相关性的研究进行综述。