几丁聚糖纳米颗粒的动态光散射研究

摘要

The chitosan nanoparticles were prepared by ionic gelation method and the size distribution and Zeta potential were measured by dynamic light scattering technique. The results showed that the size distribution of chitosan nanoparticles was from unimodal to bimodal with the TPP content decreasing and it indicated that the aggregation effect between nanoparticles was caused by the TPP content decreasing. The Zeta potential reduced gradually with the TPP content decreased. This was because more NH3+ions on the surface of chitosan nanoparticles neutralized triphosphoric groups for TPP content increasing.%利用离子凝胶法制备几丁聚糖纳米颗粒，并用动态光散射测量所得颗粒的粒径分布与界面电位。研究结果发现，随着CS/TPP比值的减小，几丁聚糖纳米颗粒的粒径由单峰分布转变为双峰分布，说明三聚磷酸钠含量的增加会使几丁聚糖纳米颗粒之间产生聚集效应。界面电位值随着CS/TPP比值的减小而逐渐下降，原因是三聚磷酸钠浓度的增加使几丁聚糖纳米颗粒表面上更多的NH3+离子与三聚磷酸根离子反应中和的缘故。