Objective To study alprostadil combined with low-dose dopamine clinical efficacy of treatment. Methods January 2015 - January 2016 period of chronic heart failure and renal dysfunction in patients admitted to our hospital 90 cases of Cardiology as a research object, using the coin toss method were divided into observation group and control group all 45 cases, the observation group were conventional therapy plus alprostadil combined with low-dose dopamine for treatment, control group patients with conventional therapy and oral digoxin, the clinical efficacy were observed and clinical indicators of heart and kidney function before and after treatment. Results The effective rate of the observation group and the total effective rate were 31.11%, 95.56% was significantly higher than 13.33%, 80.00%, P<0.05; obser-vation group after treatment LVEDD (53.08 ± 7.03) mm lower than the control group ( 56.03 ± 3.83) mm, LVEF (38.10 ± 2.48)%, BUN(5.58 ± 3.17) mmol / L, respectively, higher than that (34.56 ± 2.36)%, (7.09 ± 3.08) mmol / L, P<0.05. Conclusion Alprostadil combined with low-dose dopamine in treatment of chronic heart failure and renal dysfunction significant effect, is worthy of wide application and promotion.%目的：研究前列地尔联合小剂量多巴胺治疗的临床疗效。方法选取2015年1月—2016年1月期间该院心内科收治的慢性心衰合并肾功能不全患者90例作为研究对对象,采用硬币投掷法将患者分为观察组和对照组,每组各45例,观察组患者进行常规治疗+前列地尔联合小剂量多巴胺进行治疗,对照组患者进行常规治疗+口服地高辛,观察两组患者的临床疗效及治疗前后心肾功能的临床指标。结果观察组的显效率及总有效率分别为31.11%、95.56%明显高于对照组的13.33%、80.00%,P<0.05；观察组治疗后LVEDD(53.08±7.03)mm低于对照组(56.03±3.83)mm,LVEF(38.10±2.48)%、BUN(5.58±3.17)mmol/L分别高于对照组(34.56±2.36)%、(7.09±3.08)mmol/L, P<0.05。结论前列地尔联合小剂量多巴胺治疗慢性心衰合并肾功能不全疗效显著,值得临床的广泛应用和推广。
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