猪是研究肥胖及代谢综合征的理想模型

摘要

At presrnt,obesity is increasing at an alarmin g rate in global,and it is the major health issue facing whole human.The development of obesity research is limited,because much of the scientific literature addressing obesity has originated with rodent models,there are many difference in physiology between rodent models and humans (i.e.,adipsin,leptin,resistin,tumor necrosis factor-α,and other adipokines)have hindered the translation of rodent data into application for humans.Thus,there is considerable interest among researchers in the development of comparative animal models.The pig is an exceptional restenosis model,and is emerging rapidly as a biomedical model for energy metabolism and obesity in humans because it is devoid of brown fat postnatally and because of their similar metabolic features,cardiovascular systems,and proportional organ sizes.This article highlights the current literature devoted to the development of porcine models for obesity and the metabolic syndrome,and compared with human,with a particular emphasis on the role of adipose tissue and adipokines in the regulation of energy balance and the inflammation associated with obesity.%目前，肥胖在全球以惊人的速度增加，同时也是全人类面临的主要健康问题之一。研究者对于肥胖的研究进展是相当缓慢的，因为目前对肥胖的研究主要是以鼠作为动物医学模型，然而人与鼠之间在生理学上存在许多差异，比如脂肪酶、来普汀、抵抗素、肿瘤抑制因子α和其他细胞因子，从而很难将鼠的研究结果应用到人类身上。因此，研究者对发展另外一种动物医学研究模型非常地感兴趣，猪作为一种特殊的模型正快速地成为研究人类能量代谢和肥胖的生物医学模型，因为猪在出生后棕色脂肪会消失，具有与人类相似的代谢特征、心血管系统和适当的器官大小。本文综述了猪作为动物医学模型来研究肥胖和代谢综合征得到的结果，并与人进行了比较，特别强调了脂肪组织和细胞因子在调节能量平衡和肥胖相关炎症上的作用。