多索茶碱注射液与注射用氟氯西林钠两种药物配伍稳定性的实验研究

摘要

目的：探讨多索茶碱注射液与注射用氟氯西林钠分别在0.9％氯化钠注射液和5％葡萄糖注射液中配伍的稳定性。方法于室温（25℃）条件下，分别观察及测定8h内配伍液的外观、pH值，并用高效液相色谱法测定配伍液中两种药物成分的含量，计算回收率并判明二者的线性关系。结果两药配伍后8 h内，除在5 h时点的5％葡萄糖注射液中检测到多索茶碱的含量有降低外，其余外观、pH值、含量、回收率等均无明显变化，两药检测浓度均呈良好线性关系。结论多索茶碱注射液与注射用氟氯西林钠可于常温下在0.9％氯化钠注射液和5％葡萄糖注射液中配伍使用，但在5％葡萄糖注射液中配伍时宜于4h内完成滴注。%OBJECTIVE To study the compatible stability of doxofylline injection and flucloxacillin sodium in the Sodium Chloride Injection (0.9%) and Glucose Injection (5%) respectively.METHODS The appearance of the liquid was observed and its pH value was measured ,content of two kinds of mixture of drug components was de-termined with high performance liquid chromatography at the room temperature ( 25℃) conditions in 8 hours.RESULTS In addition to the content of doxofylline in the 5% Glucose Injection was decreased in 5 h, the appearance ,pH value and content had no obvious change with 8 h after two medicines compatibility.CONCLUSION Doxofylline Injection and flucloxacillin sodium for injection can be compability in the 0.9% Sodium Chloride In-jection and 5% Glucose Injection at room temperature , but the infusion of compatibility in 5% Glucose Injection should be completed in 4h.