替米沙坦联合瑞舒伐他汀钙对动脉粥样硬化颈动脉内膜-中层厚度的影响

摘要

目的：研究替米沙坦联合瑞舒伐他汀钙对动脉粥样硬化颈动脉内膜-中层厚度（ IMT）的影响。方法选取2015年1月至2015年12月间来我院治疗的116例原发性高血压伴动脉粥样硬化患者，随机分为两组，对照组给予替米沙坦治疗，观察组在此基础上联合应用瑞舒伐他汀钙治疗，分析比较两组间血压、血脂及IMT的变化情况。结果两组患者治疗后，观察组患者血压、血脂指标显著好于对照组（ P<0.05），两组IMT值治疗前后均有显著下降（P<0.05），而且观察组IMT值显著低于对照组（P<0.05）。结论对原发性高血压伴动脉粥样硬化患者联合应用替米沙坦与瑞舒伐他汀钙治疗，不但能有效控制血压及血脂情况，还能有效降低颈动脉内膜-中层厚度，从而延缓动脉粥样硬化病变的进程。%ABSTRACT:OBJECTIVE To study the clinical effect of Telmisartan and Rosuvastatin in the carotid intimal-me-dial thickness ( IMT) for patients with atherosclerotic cerebral infarction.METHODS 116 patients with atheroscle-rotic cerebral infarction treated from January 2015 to December 2015 in our hospital were selected.The subjects were randomly divided into two groups;the control group took Telmisartan;the observation group took Telmisartan and Ro-suvastatin.The changes of blood pressure,blood lipid and IMT were compared between the two groups.RESULTS After treatment,the blood pressure and blood lipid for observation group was significantly better than that of control group (P<0.05);after treatment,the value of IMT for two groups was significantly lower than before (P<0.05);the value of IMT for observation group was even lower than that of control group ( P<0.05).CONCLUSION For patients with atherosclerotic thrombotic cerebral infarction combined with telmisartan and rosuvastatin atorvastatin cal-cium therapy,not only can effectively control blood pressure and blood fat can effectively reduce the carotid artery in-tima media thickness,thus delaying the process of atherosclerotic lesions.