颌骨放射性骨坏死动物模型的研究进展

摘要

颌骨放射性骨坏死(osteoradionecrosis of jaws,ORNJ)是头颈部肿瘤放疗后最严重的并发症之一.该疾病进展慢,病程长,发病机制尚未完全明确.由于缺乏有效的治疗措施,临床处理较为棘手.ORNJ动物模型对于研究该疾病的发病机制、预防及治疗均有重要意义.现就ORNJ动物建模在动物选择,建模方案,评估指标及模型应用等方面进行综述.%Osteoradionecrosis of jaws(ORNJ)is one of the most severe complications following radiotherapy for patients with head and neck cancer.ORNJ develops slowly and has long duration of illness.The pathogenesis and pathophysiology of ORNJ still remain un-clear.Due to the lack of effective therapeutics,this disease has long been a difficult clinical problem.It's meaningful to establish animal models of ORNJ for exploring its pathogenesis,disease prevention and therapeutic intervention. This review introduces and summarizes the animal choice,building methods,evaluation indicators and application of ORNJ model.